According to the Planning Guide, you must now make sure all business requirements are fulfilled.
Make sure your IT-organization, among many other things, performs a regular backup of your Nodinite installation.
You should use the Nodinite Database Monitoring Agent, to make sure that backups are regulary taken, regardless of who is responsible. In the end, if the IT-department fails to backup your environment, and it gets lost, it will be your problem!
Hardening the Web Client, and other Core Services, is something we documented on the How to perform hardening on your Nodinite installation page.
Make sure to stay up to date, both due to fact that new features are constantly being added to Nodinite. We also add security-related features as technologies advance.